Disruption of Thyroid Hormone Function by Environmental Pollutants
نویسندگان
چکیده
منابع مشابه
Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals.
Thyroid hormone is well-known to play essential roles in brain development. Therefore, environmental factors that interfere with thyroid function or thyroid hormone action may produce deleterious effects on brain development by interfering with thyroid hormone action in the developing brain. The purpose of this review is to identify in broad terms the gaps in our knowledge of thyroid hormone ac...
متن کاملImpact of low-level thyroid hormone disruption induced by propylthiouracil on brain development and function.
The critical role of thyroid hormone (TH) in brain development is well-established. Evidence shows that severe deficiencies lead to significant neurological dysfunction. Much less information is available on more modest perturbations of TH on brain function. The present study induced varying degrees of developmental hypothyroidism by administration of low doses of the TH synthesis inhibitor, pr...
متن کاملThyroid hormone resistance syndrome. Inhibition of normal receptor function by mutant thyroid hormone receptors.
Thyroid hormone (T3) resistance is inherited in most cases in an autosomal dominant manner. The disorder is characterized by elevated free thyroid hormone levels and partial resistance to thyroid hormone at the cellular level. Distinct single amino acid substitutions in the ligand binding domain of the beta form of the thyroid hormone receptor have been described in two kindreds with this disor...
متن کاملDisruption of Thyroid Hormone Receptor–Mediated Transcription and Thyroid Hormone–Induced Purkinje Cell Dendrite Arborization by Polybrominated Diphenyl Ethers
BACKGROUND Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants and are becoming a ubiquitous environmental contaminant. Adverse effects in the developing brain are of great health concern. OBJECTIVE We investigated the effect of PBDEs/hydroxylated PBDEs (OH-PBDEs) on thyroid hormone (TH) receptor (TR)-mediated transcription and on TH-induced dendrite arborization of cere...
متن کاملHistamine and Thyroid Hormone Function*
In an earlier paper in this journal I reviewed evidence suggesting that histamine serves as an important regulator of the microcirculatory system (Schayer, 1968). Since the metabolism of cells depends on their internal environment, and this depends on distribution of nutrients and removal of wastes through the capillaries, it seems evident that any hormone with a sustained circulatory effect co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Health Science
سال: 2009
ISSN: 1344-9702,1347-5207
DOI: 10.1248/jhs.55.147